Gutgard® is entirely different from deglycyrrhized
licorice (DGL) with respect to chemistry and composition,
manufacturing process, mechanisms of action and physicochemical properties.
Gutgard® is an innovative, clinically researched, bioactive for gut health. As
opposed to focusing solely on deglycyrrhization, It is a flavonoid-rich extract
of G. glabra root. It is entirely different from deglycyrrhized licorice (DGL) with respect
to chemistry and composition, manufacturing process, mechanisms of action, and
physicochemical properties.
Gutgard® is extracted using a soft and unique extraction process to capture the
bioactive flavonoid chemistry of the plant. A classical extract like DGL does not contain
any significant quantity of flavonoids. Most of the generic DGL-based extracts available
in the market are by-products of a process to manufacture glycyrrhizin from licorice.
Gutgard® is standardized to contain ≥10% total flavonoids (w/w) and also ≤0.5%
glycyrrhizin to avoid undesirable side effects. More than 50 flavonoids have been
identified in Gutgard® by hyphenated analytical techniques like LC-MS, including
isoflavans (glabridin), flavones (Ex: licoflavone A), flavanones (Ex: glabrol), chalcones (Ex:
isoliquiritigenin), isoflavones (Ex: Formononetin) etc 19 Batch to batch consistency of
the flavonoid profile is monitored with the help of HPLC and other advanced analytical
test methods.
Licorice flavonoids have been shown to have beneficial activity for digestive
complaints. Gutgard® itself has been clinically tested and shown to have efficacy for
addressing these complaints. Gutgard® (with LC-MS based identification of flavonoids)
showed far superior antiulcer (in-house report) and anti-Helicobacter pylori activity30
than regular aqueous based deglycyrrhizinated (DGL) extracts. Because of the
concentrated nature of the flavonoids, the efficacious intake level for Gutgard® is much
lower than that needed for DGL - 150 mg/day versus 1500 mg/day.
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